The sixth season of the Tamil-language version of the reality TV show Bigg Boss began airing on October 4, 2021, on Vijay Television. The show is hosted by Kamal Haasan and will run for 105 days, with contestants living in a specially constructed house and being monitored by cameras. The winner of the season will receive a cash prize. The show has been a popular program in Tamil Nadu and has featured a mix of celebrities and non-celebrities as contestants.
| ADK | Eliminated | |
| Amudhavanan | Eliminated | |
| Asal | Eliminated | |
| Aysha | Eliminated | |
| Azeem | Winner | |
| Dhanalakshmi | Eliminated | |
| GP Muthu | Eliminated | |
| Janany | Eliminated | |
| Maheswari | Eliminated | |
| Manikanta | Eliminated | |
| Nivaa | Eliminated | |
| Queency | Eliminated | |
| Rachitha | Eliminated | |
| Ram | Eliminated | |
| Robert Master | Eliminated | |
| Shanthi | Eliminated | |
| Sheriina | Eliminated | |
| Shivin Ganesan | Eliminated | |
| Vikraman | Runner! | |
| VJ Kathirravan | Eliminated |
